Table 4.
Top 3 DAVID functional annotation charts constructed using all upregulated mRNAs in obese pigs
| mRNA | Name | Function |
|---|---|---|
| Aging | ||
| LOXL2 | lysyl oxidase-like 2 | biogenesis of connective tissue |
| PTGS1 | prostaglandin-endoperoxide synthase 1 | regulates angiogenesis in endothelial cells |
| PRKCA | protein kinase C, alpha | involved in diverse cellular signaling pathways |
| TFRC | transferrin receptor | development of erythrocytes and the nervous system |
| Growth Factor | ||
| BTC | betacellulin | mitogen for epithelial cells |
| BMP3 | bone morphogenetic protein 3 | induces bone formation |
| BMP6 | bone morphogenetic protein 6 | induces bone formation |
| NOV | nephroblastoma overexpressed gene | associated with extracellular matrix development |
| Positive Regulation of Developmental Process | ||
| KLF10 | Kruppel-like factor 10 | transcriptional repressor |
| BTC | betacellulin | mitogen for epithelial cells |
| BMP6 | bone morphogenetic protein 6 | induces bone formation |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | nitric oxide generation |
| PRKCA | protein kinase C, alpha | involved in diverse cellular signaling pathways |
DAVID Bioinformatics Resource 6.7 was utilized, the upregulated mRNAs in obese pigs (>1.5-fold above lean, P value < 0.05) were input, and various functional outcome measures were obtained.