Table 5.

Top 3 DAVID functional annotation charts constructed using all downregulated mRNAs in obese pigs

mRNA	Name	Function
Proteinaceous Extracellular Matrix
ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	cleaves aggrecan, a cartilage proteoglycan
FRAS1	Fraser syndrome 1	extracellular matrix protein involved in epidermal-basement membrane adhesion
MAMDC2	MAM domain containing 2	extracellular domain that mediates protein-protein interactions
ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	hydrolysis of ATP and other nucleotides
HMCN1	hemicentin 1	extracellular matrix stabilization
WNT16	wingless-type MMTV integration site family, member 16	signaling protein associated with developmental processes
Protein Ubiquitination
FBXW11	F-box and WD repeat domain containing 11	substrate recognition component involved with degradation of target protein
DDB2	damage-specific DNA binding protein 2	required for DNA binding in response to cellular damage
TRIP12	thyroid hormone receptor interactor 12	ligase involved in DNA repair
UBE3C	ubiquitin protein ligase E3C	involved in formation of poly-ubiquitin chains
Sulfur Metabolic Process
PAPSS2	3′-phosphoadenosine 5′-phosphosulfate synthase 2	bifunctional enzyme with both ATP sulfurylase and APS kinase activity
MAMDC2	MAM domain containing 2	extracellular domain that mediates protein-protein interactions
CSGALNACT2	chondroitin sulfate N-acetylgalactosaminyltransferase 2	elongation during chondroitin sulfate synthesis
TPST2	tyrosylprotein sulfotransferase 2	catalyzes the O-sulfation of tyrosine residues

DAVID Bioinformatics Resource 6.7 was utilized, the downregulated mRNAs in obese pigs (>−1.5-fold below lean, P value < 0.05) were input, and various functional outcome measures were obtained.