Table 6.

GO gene lists generated using DAVID Bioinformatics online software

GO Category	Top Function	mRNAs Involved
Upregulated (Obese > 1.5-fold Over Lean, P < 0.05) GO Categories
Biological process	development	KLF10, MFNG, BMP3, BMP6, CTGF, EFNA5, ETV6, FAM83H, GPM6B, LMBR1, LOXL2, MLL2, PTCH2, PDGFRA, PHLDA3, PTGS1, PRKCA, SEMA3B, SHROOM3, LOC100130902, TFRC, MAFF, WNT2B
Cellular component	extracellular region	ADAMTS5, MFNG, BTC, BMP3, BMP6, CTGF, EFNA5, LOXL1, LOXL2, NOV, RTN3, WNT2B
Molecular function	growth factor activity	BTC, BMP3, BMP6, CTGF, NOV
Downregulated (Obese > −1.5-fold Below Lean, P < 0.05) GO Categories
Biological process	RNA processing	DDX46, FTSJ1, PAPD4, RBM25, SR140, LUC7L3, CPSF6, DUSP11, HNRNPK, IVNS1ABP, POLR2B, SRRM1, SF3B1, SF3B3
Cellular component	nucleoplasm part	DDX46, OGT, RBM25, SMAD9, SON, TAF5, LUC7L3, CPSF6, HDAC3, IVNS1ABP, POLR2B, SRRM1, SF3B1, ZFHX3
Molecular function	DNA binding	AEBP1, DBP, NOTCH1, OTUD7B, PRDM10, SMAD9, SON, SP4, TAF15, TAF5, UPF1, LUC7L3, DDB2, HNRNPK, HDAC3, HOXB6, MBD6, MEF2D, POLR2B, SRRM1, SIM2, TRPS1, ZFHX3, ZNF131, ZNF211, ZNF267, ZNF333, ZNF527, ZNF688, ZNF689, ZNF771

Upregulated and downregulated gene lists were entered separately.

GO, Gene Ontology.