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Effect of MMP inhibitor on fibroblast-mediated collagen gel contraction. Human lung fibroblast-populated collagen gels were released in 60-mm tissue culture dishes with or without the MMP inhibitor (GM-6001, 1 μM). Gel size was measured daily with an image analyzer. Vertical axis, gel size expressed as % initial size; horizontal axis, time (days of culture). *P < 0.05 compared with control cells. Data are shown as means ± SE.
