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Averaged time-course changes in cutaneous vascular conductance during local heating. Baseline, initial peak, nadir, and plateau cutaneous vascular conductance obtained from individuals were averaged and compared across the four drug sites. Time 0 indicates the initiation of local heating. Tempol, 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl, a superoxide dismutase mimetic; l-NNA, NG-nitro-l-arginine (a nonspecific nitric oxide synthase inhibitor).
