Fig. 12.

Maximum diameter, myogenic tone, and BK_Ca function are similar in SEAs from Young and Old. A (scale bar = 100 μm) and B: typical images of SEAs from Young (A) and Old (B) depicting (from left to right in each panel) maximal diameters (Max) at 80 cmH₂O in the absence of myogenic tone, development of myogenic tone in PSS containing 1.8 mM Ca²⁺, and constriction induced by the BK_Ca blocker paxilline (1 μM). C–E: summary data (means ± SE) for maximum diameters (C), myogenic tone (percent relative to maximum diameter; D), and the response to paxilline (percent constriction; E) for SEAs from Young (n = 10 vessels from 10 mice) and Old (n = 12 vessels from 12 mice). There was no significant difference in maximum diameters of SEAs from Young vs. Old (C; P > 0.05). Similarly, SEAs from Young and Old had no significant difference in the levels of myogenic tone (D; P > 0.05) or constriction induced by paxilline (E; P > 0.05).