Fig. 4.
Inhibition of STOCs in SEA SMCs from Young and Old. BKCa blockers iberiotoxin and tetraethylammonium (TEA) and ryanodine receptor (RyR) antagonist tetracaine inhibited STOCs recorded at +30 mV in SEA SMCs from Young and Old. Data are means ± SE for the amplitude (A, C, and E) and frequency (B, D, and F) of STOCs. A and B: 100 nM iberiotoxin (n = 8 cells from 3 mice for Young and n = 10 cells from 4 mice for Old). C and D: 1 mM TEA (n = 15 cells from 6 mice for Young and n = 12 cells from 6 mice for Old). E and F: 100 μM tetracaine (n = 6 cells from 3 mice for Young and n = 8 cells from 3 mice for Old). *P < 0.05 vs. Control.