Fig. 6.

TEA inhibits whole-cell current densities of SEA SMCs irrespective of paxilline. Data are mean current densities ± SE (in pA/pF) in the absence (Control) or presence of TEA (1 mM), as indicated. A and B: TEA inhibits whole-cell current density at positive membrane potentials in SMCs from Young (A; n = 32 cells from 14 mice) or Old (B; n = 30 cells from 14 mice). C: TEA-sensitive currents in SMCs from Young were not different from those recorded in SMCs from Old. D and E: TEA inhibits whole-cell current densities in the presence of paxilline in SMCs from Young (D; n = 7 from 4 mice) and Old (E; n = 8 from 3 mice), respectively. *P < 0.05 compared with Control.