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Example of 10ms/Hz, 1 min sonications. Pressures at L1-L4 were 267, 300, 366 and 444 kPa, respectively. The animal was sacrificed in 48 hours. T1-weighted MR image (a) shows good BBB disruptions, and mild edemas were seen on the T2-weighted image (b). In H&E (c-e), scattered hemorrhages were found, but normal neurons (short arrow in e) were seen adjacent to degenerated neurons (long arrows). No large area of discrete lesion was formed.
