Comparison 7.
Vaginal misoprostol versus surgery
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Complete miscarriage | 3 | 154 | Risk Ratio (M-H, Fixed, 95% CI) | 0.90 [0.82, 0.99] |
| 1.1 Gestation < 13 weeks | 3 | 154 | Risk Ratio (M-H, Fixed, 95% CI) | 0.90 [0.82, 0.99] |
| 1.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 1.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [00.0, 0.0] |
| 2 Surgical evacuation | 3 | 315 | Risk Ratio (M-H, Random, 95% CI) | 0.18 [0.08, 0.44] |
| 2.1 Gestation < 13 weeks | 3 | 315 | Risk Ratio (M-H, Random, 95% CI) | 0.18 [0.08, 0.44] |
| 2.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Random, 95% CI) | 0.0 [00.0, 0.0] |
| 2.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 3 Death or serious complication | 2 | 132 | Risk Ratio (M-H, Fixed, 95% CI) | 1.0 [0.04, 22.64] |
| 3.1 Gestation < 13 weeks | 2 | 132 | Risk Ratio (M-H, Fixed, 95% CI) | 1.0 [0.04, 22.64] |
| 3.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 3.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [00.0, 0.0] |
| 4 Unplanned surgical intervention | 3 | 315 | Risk Ratio (M-H, Random, 95% CI) | 5.56 [1.11, 27.90] |
| 4.1 Gestation < 13 weeks | 3 | 315 | Risk Ratio (M-H, Random, 95% CI) | 5.56 [1.11, 27.90] |
| 4.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Random, 95% CI) | 0.0 [00.0, 0.0] |
| 4.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 5 Blood transfusion | 3 | 241 | Risk Ratio (M-H, Fixed, 95% CI) | 1.82 [0.21, 15.70] |
| 5.1 Gestation < 13 weeks | 3 | 241 | Risk Ratio (M-H, Fixed, 95% CI) | 1.82 [0.21, 15.70] |
| 5.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 5.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [00.0, 0.0] |
| 6 Haemorrhage | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 6.1 Gestation < 13 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 6.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 6.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 7 Blood loss | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 7.1 Gestation < 13 weeks | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 7.2 Gestation 13-23 weeks | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 7.3 Gestation not specified | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 8 Anaemia | 1 | 36 | Risk Ratio (M-H, Fixed, 95% CI) | 1.71 [0.24, 12.24] |
| 8.1 Gestation < 13 weeks | 1 | 36 | Risk Ratio (M-H, Fixed, 95% CI) | 1.71 [0.24, 12.24] |
| 8.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 8.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 9 Days of bleeding | 2 | 131 | Mean Difference (IV, Fixed, 95% CI) | 2.76 [1.55, 3.97] |
| 9.1 Gestation < 13 weeks | 2 | 131 | Mean Difference (IV, Fixed, 95% CI) | 2.76 [1.55, 3.97] |
| 9.2 Gestation 13-23 weeks | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 9.3 Gestation not specified | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 10 Pain relief | 3 | 313 | Risk Ratio (M-H, Fixed, 95% CI) | 1.75 [1.21, 2.54] |
| 10.1 Gestation < 13 weeks | 3 | 313 | Risk Ratio (M-H, Fixed, 95% CI) | 1.75 [1.21, 2.54] |
| 10.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 10.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 11 Pelvic infection < 14 days | 4 | 338 | Risk Ratio (M-H, Fixed, 95% CI) | 1.27 [0.37, 4.42] |
| 11.1 Gestation < 13 weeks | 4 | 338 | Risk Ratio (M-H, Fixed, 95% CI) | 1.27 [0.37, 4.42] |
| 11.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 11.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 12 Cervical damage | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 12.1 Gestation < 13 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 12.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 12.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 13 Digestive disorders | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 13.1 Gestation < 13 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 13.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 13.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 14 Hypertensive disorders | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 14.1 Gestation < 13 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 14.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 14.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 15 Duration of hospital stay | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 15.1 Gestation < 13 weeks | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 15.2 Gestation 13-23 weeks | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 15.3 Gestation not specified | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 16 Psychological effects | 0 | 0 | Std. Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 16.1 Gestation < 13 weeks | 0 | 0 | Std. Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 16.2 Gestation 13-23 weeks | 0 | 0 | Std. Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 16.3 Gestation not specified | 0 | 0 | Std. Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 17 Subsequent fertility | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 17.1 Gestation < 13 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 17.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 17.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 18 Women’s views/satisfaction | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 18.1 Gestation < 13 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 18.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 18.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 19 Women’s views/satisfaction - continuous data | 2 | 131 | Std. Mean Difference (IV, Random, 95% CI) | 1.01 [0.01, 2.00] |
| 19.1 Gestation < 13 weeks | 2 | 131 | Std. Mean Difference (IV, Random, 95% CI) | 1.01 [0.01, 2.00] |
| 19.2 Gestation 13-23 weeks | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 19.3 Gestation not specified | 0 | 0 | Std. Mean Difference (IV, Random, 95% CI) | 0.0 [0.0, 0.0] |
| 20 Death | 1 | 38 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 20.1 Gestation < 13 weeks | 1 | 38 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 20.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 20.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 21 Serious morbidity | 1 | 94 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 21.1 Gestation < 13 weeks | 1 | 94 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 21.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 21.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 22 Pathology of fetal/placental tissue | 0 | 0 | Std. Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 22.1 Gestation < 13 weeks | 0 | 0 | Std. Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 22.2 Gestation 13-23 weeks | 0 | 0 | Std. Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 22.3 Gestation not specified | 0 | 0 | Std. Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 23 Costs | 0 | 0 | Std. Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 23.1 Gestation < 13 weeks | 0 | 0 | Std. Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 23.2 Gestation 13-23 weeks | 0 | 0 | Std. Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 23.3 Gestation not specified | 0 | 0 | Std. Mean Difference (IV, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 24 Nausea | 3 | 156 | Risk Ratio (M-H, Fixed, 95% CI) | 1.37 [0.58, 3.22] |
| 24.1 Gestation < 13 weeks | 3 | 156 | Risk Ratio (M-H, Fixed, 95% CI) | 1.37 [0.58, 3.22] |
| 24.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 24.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 25 Vomiting | 2 | 131 | Risk Ratio (M-H, Fixed, 95% CI) | 1.48 [0.25, 8.93] |
| 25.1 Gestation < 13 weeks | 2 | 131 | Risk Ratio (M-H, Fixed, 95% CI) | 1.48 [0.25, 8.93] |
| 25.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 25.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 26 Diarrhoea | 2 | 131 | Risk Ratio (M-H, Fixed, 95% CI) | 4.30 [0.52, 35.36] |
| 26.1 Gestation < 13 weeks | 2 | 131 | Risk Ratio (M-H, Fixed, 95% CI) | 4.30 [0.52, 35.36] |
| 26.2 Gestation 13-23 weeks | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| 26.3 Gestation not specified | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |