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. Author manuscript; available in PMC: 2014 Jun 3.
Published in final edited form as: Cochrane Database Syst Rev. 2010 Jan 20;(1):CD007223. doi: 10.1002/14651858.CD007223.pub2

Comparison 14.

Oral misoprostol: 600 ug versus 1200 ug

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Complete miscarriage 2 464 Risk Ratio (M-H, Fixed, 95% CI) 1.00 [0.93, 1.07]
 1.1 Gestation < 13 weeks 2 464 Risk Ratio (M-H, Fixed, 95% CI) 1.00 [0.93, 1.07]
 1.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 1.3 Gestation not specified 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
2 Surgical evacuation 1 295 Risk Ratio (M-H, Fixed, 95% CI) 0.76 [0.29, 1.99]
 2.1 Gestation < 13 weeks 1 295 Risk Ratio (M-H, Fixed, 95% CI) 0.76 [0.29, 1.99]
 2.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 2.3 Gestation not specified 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
3 Death or serious complication 1 295 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 3.1 Gestation <13 weeks 1 295 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 3.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 3.3 Gestation not specified 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
4 Unplanned surgical intervention 1 295 Risk Ratio (M-H, Fixed, 95% CI) 0.76 [0.29, 1.99]
 4.1 Gestation < 13 weeks 1 295 Risk Ratio (M-H, Fixed, 95% CI) 0.76 [0.29, 1.99]
 4.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 4.3 Gestation not specified 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
5 Blood transfusion 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 5.1 Gestation < 13 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 5.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 5.3 Gestation not specified 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
6 Haemorrhage 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 6.1 Gestation < 13 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 6.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 6.3 Gestation not specified 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
7 Blood loss 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 7.1 Gestation < 13 weeks 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 7.2 Gestation 13-23 weeks 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 7.3 Gestation not specified 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
8 Anaemia 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 8.1 Gestation < 13 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 8.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 8.3 Gestation not specified 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
9 Days of bleeding 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 9.1 Gestation < 13 weeks 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 9.2 Gestation 13-23 weeks 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 9.3 Gestation not specified 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
10 Pain relief 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 10.1 Gestation < 13 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 10.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 10.3 Gestation not specified 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
11 Pelvic infection 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 11.1 Gestation < 13 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 11.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 11.3 Gestation not specified 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
12 Cervical damage 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 12.1 Gestation < 13 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 12.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 12.3 Gestation not specified 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
13 Digestive disorders 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 13.1 Gestation < 13 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 13.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 13.3 Gestation not specified 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
14 Hypertensive disorders 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 14.1 Gestation < 13 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 14.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 14.3 Gestation not specified 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
15 Duration of hospital stay 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 15.1 Gestation <13 weeks 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 15.2 Gestation 13-23 weeks 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 15.3 Gestation not specified 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
16 Psychological effects 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 16.1 Gestation < 13 weeks 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 16.2 Gestation 13-23 weeks 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 16.3 Gestation not specified 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
17 Subsequent fertility 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 17.1 Gestation < 13 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 17.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 17.3 Gestation not specified 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
18 Women’s views/satisfaction 2 460 Risk Ratio (M-H, Fixed, 95% CI) 1.02 [0.96, 1.09]
 18.1 Gestation <13 weeks 2 460 Risk Ratio (M-H, Fixed, 95% CI) 1.02 [0.96, 1.09]
 18.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 18.3 Gestation not specified 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
19 Women’s views/satisfaction - continuous data 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 19.1 Gestation <13 weeks 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 19.2 Gestation 13-23 weeks 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 19.3 Gestation not specified 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
20 Death 1 295 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 20.1 Gestation <13 weeks 1 295 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 20.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 20.3 Gestation not specified 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
21 Serious morbidity 1 295 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 21.1 Gestation < 13 weeks 1 295 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 21.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 21.3 Gestation not specified 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
22 Pathology of fetal/placental tissue 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 22.1 Gestation < 13 weeks 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 22.2 Gestation 13-23 weeks 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 22.3 Gestation not specified 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
23 Costs 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 23.1 Gestation < 13 weeks 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 23.2 Gestation 13-23 weeks 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
 23.3 Gestation not specified 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
24 Nausea 2 463 Risk Ratio (M-H, Random, 95% CI) 1.19 [0.57, 2.46]
 24.1 Gestation <13 weeks 2 463 Risk Ratio (M-H, Random, 95% CI) 1.19 [0.57, 2.46]
 24.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Random, 95% CI) 0.0 [0.0, 0.0]
 24.3 Gestation not specified 0 0 Risk Ratio (M-H, Random, 95% CI) 0.0 [0.0, 0.0]
25 Vomiting 2 463 Risk Ratio (M-H, Fixed, 95% CI) 1.01 [0.60, 1.72]
 25.1 Gestation <13 weeks 2 463 Risk Ratio (M-H, Fixed, 95% CI) 1.01 [0.60, 1.72]
 25.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 25.3 Gestation not specified 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
26 Diarrhoea 1 294 Risk Ratio (M-H, Fixed, 95% CI) 0.73 [0.55, 0.97]
 26.1 Gestation < 13 weeks 1 294 Risk Ratio (M-H, Fixed, 95% CI) 0.73 [0.55, 0.97]
 26.2 Gestation 13-23 weeks 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 26.3 Gestation not specified 0 0 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]