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. 2014 Jun 3;2:52. doi: 10.3389/fped.2014.00052

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Copyright © 2014 Pini, Scusa, Benincasa, Bottiglioni, Congiu, Vadhatpour, Romanelli, Gemo, Puccetti, McNamara, O’Leary, Corvin, Gill and Tropea.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of IGF1 treatment differ in different treatment cycles. Plots of average (T1–T0) and SE in cycle 1 and cycle 2 for Negative features (A), Positive features (B), and Negative plus positive features (C). The data suggest that the negative features improved more in the first cycle than in the second (A). Conversely, the positive features improved more in the second cycle than the first. (B) Considering both positive and negative features, the effect of the treatment was comparable in both cycles (C).