Table 6.

Differential scores of ISS scores during cycles.

ISS components	Cycle 1		Cycle 2
Differential score	Effect	Preserve	Effect	Preserve
Growth and development	−1	1	−1	2
Locomotor apparatus	0	0	0	0
Movement	0	0	0	−1
Cortical function	1	0	−1	1
Autonomic function	−1	0	0	−1

This table summarizes the differential scores for each component of the ISS (listed on the left), considering the difference at the end versus the beginning of the treatment (effect) and the difference after 6 months from the last administration versus the scores on the day of the last administration (preserve). The improvements are highlighted in green, and the worsenings are highlighted in red. Note that the decrease in the scoring are improvements for the ISS; on the contrary, increases in the scoring represent worsening.