Table 2. Frequency of TCRVβ CDR3 skewing in RCC and (v)SAA patients.
| RCC | (v)SAA | P | |
|---|---|---|---|
| Bone marrow skewing, no. (%) | |||
| No skewing (0–1 families skewed) | 48 of 79 (61) | 7 of 20 (35) | 0.038a |
| Weak skewing (2–5 families skewed) | 20 of 79 (25) | 10 of 20 (50) | |
| Strong skewing (>5 families skewed) | 11 of 79 (14) | 3 of 20 (15) | |
| Peripheral blood, no. (%) | |||
| No skewing (0–1 families skewed) | 50 of 83 (60) | 17 of 28 (61) | NSa |
| Weak skewing (2–5 families skewed) | 23 of 83 (28) | 8 of 28 (29) | |
| Strong skewing (>5 families skewed) | 10 of 83 (12) | 3 of 28 (11) | |
Abbreviations: CDR3, complementarity-determining region 3; NS, nonsignificant; RCC, refractory cytopenia of childhood; TCRVβ, T-cell receptor β-chain variable; (v)SAA, (very) severe aplastic anemia.
a
No skewing versus weak or strong skewing; chi-square test. Bold indicates P-value <0.05.