Table 2.
ED50 [95% CI] (mg/kg)
|
|||
---|---|---|---|
Day 7 | Day 14 | P-value | |
| |||
SAL-SAL | 3.19 [2.20 to 5.40] | 5.91 [3.90 to 10.06] | 0.098 |
SAL-MID | 4.59 [2.55 to 8.49] | 5.14 [3.40 to 7.63] | 0.382 |
MOR-SAL | 7.70 [5.66 to 13.93]* | 15.41 [11.32 to 27.85]* | 0.041 |
MOR-MID | 13.68 [10.18 to 20.97]* | 30.79 [22.83 to 53.68]*# | 0.017 |
ED50: the morphine dose that produced 50% of the anti-nociception effect
95% CI: 95% confidence intervals
P < 0.01, as compared with the SAL-SAL or SAL-MID group on Day 7 or 14
P = 0.04 as compared with the MOR-SAL group on Day 14