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. Author manuscript; available in PMC: 2015 Feb 21.
Published in final edited form as: ACS Chem Biol. 2013 Nov 20;9(2):423–432. doi: 10.1021/cb400796c

Figure 4. Metabolic pathways directed disrupted by CPF blockade of specific serine hydrolases.

Figure 4

(A) CPF inhibits MGLL and leads to an accumulation of C20:4 MAG and lowering of C20:4 FFA levels with an indirect increase in C20:4 LPA, presumably through phosphorylation of C20:4 MAG. (B) CPF inhibits FAAH and leads to an accumulation in the levels of C20:4 NAE and C20:4 NAT. (C) CPF inhibits KIAA1363 in the brain and AADAC in the liver leading to lowered levels of MAGe in the brain and elevations C16:0e/C2:0 MAGe in the liver, respectively.