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. 2013 Jul 10;110(7):1544–1553. doi: 10.1152/jn.00865.2012

Fig. 3.

Fig. 3.

nAChR-induced sIPSC frequency increase is excitation dependent. A: the ACh/At increase in sIPSC frequency in a representative ET cell is reversibly blocked by bath application of 50 μM 6,7-dinitroquinoxaline-2,3 dione (DNQX), 100 μM D-AP5, and 1 mM (+)-α-methyl-4-carboxyphenylglycine (MCPG). B: bath application of 50 μM DNQX, 100 μM D-AP5, and 1 mM MCPG significantly reduced the sIPSC frequency upon ACh/At application in 7 out of 9 cells [black; P < 0.05, Kolmogorov-Smirnov (K-S) test]. No significant block of sIPSC frequency by glutamate receptor (GluR) blockade was observed in the other 2 cells (gray). C: summary of effects with GluR blockade (n = 7 cells). GluR blockers reversibly block ACh/At-induced increases in sIPSC frequency. ***P < 0.001 (basal vs. ACh); **P < 0.01 (ACh/At alone vs. GluR block); *P < 0.05 (block vs. wash).