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. 2013 Jul 10;110(7):1722–1731. doi: 10.1152/jn.00319.2013

Fig. 4.

Fig. 4.

Uncaged GABA response rundown occurs similarly in whole cell vs. isolated patch mode, and is not rescued by inclusion of Mg-ATP in the pipette, but the degree of rundown increases progressively with each successive recording after introduction of new caged GABA solution. A: mean ± SE uncaged IPSC amplitude over successive trials normalized to the amplitude of 1st uncaging response in each cell obtained at a 10-s ISI when cells were filled with either control CsCl internal solution or CsCl with additional 5 mM MgATP. B: individual values for each cell of the slope of the line of best fit through the normalized amplitude values over 10 successive trials. Linear regression lines of best fit show positive correlations between recording order after fresh caged GABA replacement and the slope of rundown response. Solid line indicates the line of best fit for all control values, and dashed line indicates the line of best fit for cells recorded with MgATP in the pipette solution. *P < 0.05, paired t-test within cells vs. response to 1st stimulus (A); Pearson correlation (B).