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. Author manuscript; available in PMC: 2014 Jun 3.
Published in final edited form as: J Immunol. 2011 Nov 14;187(12):6463–6472. doi: 10.4049/jimmunol.1101171

Figure 3.

Figure 3

Early and robust LCMV-specific granzyme B production by CD8 T cells during LCMV infection in Kb−/−Db−/−CIITA−/− mice. Splenocytes from LCMV-infected B6, and Kb−/−Db−/−CIITA−/− mice were stained on the surface for CD8〈 and TCR®, then intracellularly for granzyme B and analyzed by flow cytometry. (A) The percentage of granzyme B producing CD8α+TCRβ+ splenocytes from B6 and Kb−/−Db−/−CIITA−/− mice at day 3, 5, 8 and 12 post LCMV-Arm infection. (B) The mean fluorescence intensity (MFI) of granzyme B expression on the CD8〈+TCR®+ cells at day 3, 5, 8 and 12 post infection.