Figure 5.

The magnetic threshold was correlated with intrinsic cellular properties. (A) The magnetic threshold of L5 pyramidal neurons (green circles) and low threshold interneurons (blue circles) recorded in the loose-patch configuration are plotted as a function of the current threshold recorded in the whole-cell configuration. (B) The magnetic thresholds of the neurons presented in (A) are plotted as a function of the input resistance. (C) The magnetic threshold recorded from L5 pyramidal neurons plotted as a function of the surface area, measured from stained neurons using Neurolucida (filled circles). The simulated magnetic threshold was calculated by systematically modifying the membrane area of a compartmental model for an L5 pyramidal neuron, while randomly modifying the surface area of the dendritic tree (line). (D) The magnetic threshold obtained from L5 pyramidal neurons in slices, in which the synaptic activity had been increased by replacing ACSF with ACSF₂, plotted as a function of the surface area measured with Nerolucida from stained neurons (filled circles). The line is the same as that presented in (C). (E) Box plot of the latency between the magnetic stimulus and the action potential recorded when the brain slice was bathed in ACSF in the presence of blockers for synaptic transmission (APV, bicuculline, CNQX). (F) Box plot of the latency between the magnetic stimulus and the action potential recorded when the brain slice was bathed in ACSF₂.