Figure 1.

Plasma HO-1 levels are elevated in individuals with diabetes with active pulmonary TB. A, Plasma concentrations of HO-1, SAA, CRP, α₂-macroglobulin, and haptoglobin from 44 individuals with active pulmonary TB without diabetes (TB) and 44 individuals with active pulmonary TB with diabetes (TB + D) were compared using Mann-Whitney tests. P values shown are adjusted for multiple measurements (Holm method). Bars represent median values. B, Receiver operating characteristic curves were used to assess the performance of HO-1 and the acute phase proteins to distinguish individuals with TB with diabetes from those with TB without diabetes (detailed C-statistic is shown on the left). AUC = area under the curve; CRP = C-reactive protein; HO-1 = heme oxygenase-1; SAA = serum amyloid protein-A.