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Effect of carbachol (CCH) on Isc and net K+ fluxes in control and DSS-treated rat distal colon. Time course of short-circuit current (Isc; A and B) and net K+ fluxes (C and D) before and after serosal addition of CCH (50 μM) under voltage-clamp conditions in control and DSS-treated rat distal colon. Net K+ fluxes were measured in the absence (open bars) and presence (closed bars) of CCH. *P < 0.001, compared with basal value in controls; £P < 0.001 compared with basal value in controls.
