Table 3.

FISH analysis of copy number gains and losses in patients with epithelioid glioblastoma

Patient #	Surgery	Copy Number Abnormalities
		PDGFRA (4q12)	EGFR (7p12)	MET (7q31)	CDKN2A (9p21)	PTEN (10q23)	SMARCB1 (22q11)
1	1	normal	polysomy 3–4	polysomy 3–4	normal	normal	normal
	2	polysomy 3–4	polysomy 3–7	polysomy 3–7	polysomy 3–4	polysomy 3–4	polysomy 3–4
2		normal	polysomy 3–4	polysomy 3–4	normal	normal	monosomy
3		normal	polysomy 3–4	polysomy 3–4	polysomy 3–4	polysomy 3–4	polysomy 3–4
4		polysomy 3–4	amplified	hemizygous deletion	homozygous deletion	normal	normal
5		normal	polysomy 3–4	polysomy 3–4	polysomy 3–4	monosomy	normal
6		polysomy 3–4	polysomy 3–4	polysomy 3–4	monosomy	hemizygous deletion	normal

Surgery 1 and 2 indicate tumor resected at diagnosis and at the time of progression, respectively