TABLE 1.

Predefined clinical specificity reference for RDT component combinations

Parasite	Combined specificityd of:
	CareStart		OptiMAL-IT
	VOM-pLDH	Pf-HRP2	Pan-pLDH	Pf-pLDH
P. knowlesia,b	±	−	±	+
P. falciparumc	−	+	±	±
P. vivax	+	−	+	−
P. malariae	+	−	+	−
P. knowlesi-P. vivax	+	−	+	+
P. knowlesi-P. falciparum	+	+	+	+
P. falciparum-P. vivax	+	+	+	+

^aP. knowlesi monoinfection or mixed P. knowlesi-P. vivax infection cannot be differentiated.

^bVOM-pLDH and pan-pLDH are not required to differentiate P. knowlesi from P. falciparum or P. vivax monoinfection.

^cPf-HRP2 is highly specific for P. falciparum; therefore, a positive Pf-HRP2 result indicates P. falciparum infection regardless of the OptiMAL-IT result.

^dSymbols: +, specific; −, not specific; ±, equivocal.