TABLE 4.
Test and parameter | Proportion, % (CI) |
P value | |||
---|---|---|---|---|---|
P. knowlesi | P. vivax | P. falciparum | P. malariae | ||
CareStart | |||||
VOM-pLDH, sensitivity | 77/178, 43 (36–51) | 29/35, 83 (70–96) | 3/85, 4 (0–8)d | 2/3, 67 (0–100) | <0.0001a |
Pf-HRP2, sensitivity | 4/183, 2 (0–4)d | 1/35, 3 (0–9)d | 86/87, 99 (97–100) | 0/3, 0 | |
OptiMAL-IT | |||||
Pan-pLDH, sensitivity | 57/189, 30 (24–37) | 25/37, 68 (52–83) | 72/92, 78 (70–87) | 2/3, 67 (0–100) | <0.0001b |
Pf-pLDH, sensitivity | 55/190, 29 (22–35) | 5/37, 14 (2–25)d | 74/92, 80 (72–89) | 0/3, 0 | <0.0001c |
CareStart (VOM-pLDH + Pf-HRP2) | |||||
Sensitivity | 74/178, 42 (34–49) | 29/35, 83 (66–93) | 82/85, 97 (90–99) | 2/3, 67 (9–99) | |
Specificity | 91/123, 74 (65–82) | 189/266, 71 (65–76) | 214/216, 99 (97–100) | 194/298, 35 (30–41) | |
OptiMAL-IT (pan-pLDH + Pf-pLDH) | |||||
Sensitivity | 61/191, 32 (25–39) | 22/37, 60 (42–75) | 75/92, 82 (72–89) | 2/3, 67 (9–99) | |
Specificity | 28/132, 21 (15–29) | 276/285, 97 (94–99) | 141/231, 39 (33–46) | 290/319, 91 (87–94) |
P. knowlesi compared against P. vivax only.
P. knowlesi compared against other Plasmodium species.
P. knowlesi compared against P. falciparum only.
False positives.