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. 2014 Jun;52(6):2053–2060. doi: 10.1128/JCM.00181-14

TABLE 4.

Sensitivity and specificity of RDTs and their components for each Plasmodium species

Test and parameter Proportion, % (CI)
P value
P. knowlesi P. vivax P. falciparum P. malariae
CareStart
    VOM-pLDH, sensitivity 77/178, 43 (36–51) 29/35, 83 (70–96) 3/85, 4 (0–8)d 2/3, 67 (0–100) <0.0001a
    Pf-HRP2, sensitivity 4/183, 2 (0–4)d 1/35, 3 (0–9)d 86/87, 99 (97–100) 0/3, 0
OptiMAL-IT
    Pan-pLDH, sensitivity 57/189, 30 (24–37) 25/37, 68 (52–83) 72/92, 78 (70–87) 2/3, 67 (0–100) <0.0001b
    Pf-pLDH, sensitivity 55/190, 29 (22–35) 5/37, 14 (2–25)d 74/92, 80 (72–89) 0/3, 0 <0.0001c
CareStart (VOM-pLDH + Pf-HRP2)
    Sensitivity 74/178, 42 (34–49) 29/35, 83 (66–93) 82/85, 97 (90–99) 2/3, 67 (9–99)
    Specificity 91/123, 74 (65–82) 189/266, 71 (65–76) 214/216, 99 (97–100) 194/298, 35 (30–41)
OptiMAL-IT (pan-pLDH + Pf-pLDH)
    Sensitivity 61/191, 32 (25–39) 22/37, 60 (42–75) 75/92, 82 (72–89) 2/3, 67 (9–99)
    Specificity 28/132, 21 (15–29) 276/285, 97 (94–99) 141/231, 39 (33–46) 290/319, 91 (87–94)
a

P. knowlesi compared against P. vivax only.

b

P. knowlesi compared against other Plasmodium species.

c

P. knowlesi compared against P. falciparum only.

d

False positives.