TABLE 5.
Performance characteristics of combined use of CareStart and OptiMAL-IT RDTs compared with those of microscopy for the diagnosis of P. knowlesi malaria
| Method and result | No. of patients with: |
% Sensitivity (CI) | % Specificity (CI) | % PPVb (CI) | % NPVc (CI) | Likelihood ratio |
||
|---|---|---|---|---|---|---|---|---|
| PCR-confirmed P. knowlesi | PCR-confirmed other Plasmodium species | Positive test | Negative test | |||||
| RDTsa | ||||||||
| Positive | 45 | 5 | 25 (19–32) | 96 (91–99) | 90 (78–97) | 47 (40–53) | 6.17 | 0.78 |
| Negative | 136 | 119 | ||||||
| Microscopy | ||||||||
| Positive | 143 | 15 | 74 (67–80) | 89 (82–94) | 91 (85–95) | 70 (63–77) | 6.57 | 0.29 |
| Negative | 50 | 118 | ||||||
a
Equivocal result for VOM-pLDH, negative result for Pf-HRP2, equivocal result for pan-pLDH, and positive result for Pf-pLDH.
b
PPV, positive predictive value.
c
NPV, negative predictive value.