TABLE 2.

MICs for 27 C. gattii and 15 C. neoformans isolates from dogs and cats

Drug and MIC measurement	MIC(s) (μg/ml) for isolates of molecular type (n)
	VGI (3)	VGII (7)	VGIII (16)	“VGIII” (1)a	VNI (14)	VNII (1)
Flucytosine
Range	0.5–1	0.5–4	0.12–16b	2	4–8	4
Geometric mean	0.79	2.00	1.83		5.12
Median		2	2		4
MIC50, MIC90		2, 4	2, 8		4, 8
Amphotericin B
Range	0.25	0.25–0.5	0.25–0.5	0.5	0.25–0.5	0.5
Geometric mean	0.25	0.45	0.39		0.48
Median		0.5	0.5		0.5
MIC50, MIC90		0.5, 0.5	0.25, 0.25		0.5, 0.5
Fluconazole
Range	2–16	4–16	0.5–32b	2	2–16	2
Geometric mean	6.34	8.00	4.36		5.38
Median		8	4		6
MIC50, MIC90		8, 8	4, 16		4, 8
Itraconazole
Range	0.03–0.25	0.03–0.25	≤0.015–0.25	0.03	0.03–0.25	0.12
Geometric mean	0.12	0.07	0.04		0.07
Median		0.06	0.03		0.06
MIC50, MIC90		0.06, 0.06	0.03, 0.06		0.06, 0.12
Posaconazole
Range	0.06–0.25	0.06–0.25	0.015–0.25	0.03	0.03–0.12	0.06
Geometric mean	0.16	0.11	0.05		0.08
Median		0.12	0.06		0.06
MIC50, MIC90		0.12, 0.12	0.06, 0.12		0.06, 0.12
Voriconazole
Range	0.03–0.12	0.015–0.25	0.015–0.12	0.015	0.015–0.06	0.03
Geometric mean	0.08	0.06	0.03		0.03
Median		0.06	0.03		0.03
MIC50, MIC90		0.06, 0.06	0.03, 0.06		0.03, 0.03

^aVGIV by URA5 RFLP but VGIII by MLST analysis.

^bVariance significantly wider than for molecular types other than VGIII.