TABLE 3.
Differences in cytokine and chemokine levels between TD and JSF patients
| Disease phase and cytokine or chemokinea | Avg level ± SD (pg/ml) in patients with: |
P valueb | |
|---|---|---|---|
| TD (n = 32) | JSF (n = 21) | ||
| Acute | |||
| TNF-α | 13.8 ± 13.5 | 35.0 ± 27.5 | <0.001 |
| IL-6 | 11.6 ± 17.2 | 65.8 ± 73.4 | <0.01 |
| IFN-γ | 73.4 ± 78.1 | 220.3 ± 228.0 | <0.001 |
| IL-8 | 13.2 ± 10.5 | 46.3 ± 35.3 | <0.001 |
| IP-10 | 3,215.9 ± 2,786.1 | 12,298.3 ± 9,539.4 | <0.001 |
| MCP-1 | 467.5 ± 492.0 | 1,365.8 ± 816.7 | <0.001 |
| MIP-1α | 15.0 ± 25.3 | 53.9 ± 41.0 | <0.001 |
| MIP-1β | 88.5 ± 63.5 | 127.7 ± 54.0 | <0.05 |
| Eotaxin | 67.1 ± 31.7 | 68.2 ± 40.1 | NS |
| Convalescent | |||
| TNF-α | 4.1 ± 4.4 | 6.8 ± 6.9 | <0.05 |
| IL-6 | 0 ± 0 | 2.2 ± 7.0 | NS |
| IFN-γ | 3.5 ± 3.7 | 16.7 ± 7.5 | NS |
| IL-8 | 6.1 ± 7.5 | 18.5 ± 23.3 | <0.01 |
| IP-10 | 550.8 ± 534.2 | 730.9 ± 805.2 | NS |
| MCP-1 | 253.9 ± 229.1 | 553.3 ± 153.3 | <0.001 |
| MIP-1α | 7.3 ± 13.9 | 9.5 ± 16.9 | NS |
| MIP-1β | 63.7 ± 46.2 | 65.7 ± 29.6 | NS |
| Eotaxin | 77.7 ± 31.8 | 65.3 ± 40.4 | NS |
a
Normal levels: TNF-α, <2.3 pg/ml; IL-6, <3.0 pg/ml; IFN-γ, <7.3 pg/ml; IL-8, <3.0 pg/ml; IP-10, MCP-1, MIP-1α and MIP-1β, normal levels not determined.
b
P values were determined by t test. NS, not significant.