TABLE 2.
Clinical characteristics of 9 episodes of Candida kefyr invasive candidiasis (8 patients)a
| Patient | Underlying disease (status)/type of chemotherapy | Mucositis | TPN | Central intravenous catheter duration (days) | ANC (at episode/days <100 during prior mo) | Timing post-chemotherapy initiation (days) | Antifungal therapy at time of first positive blood culture | Mo and yr at first positive blood culture | Duration of candidemia (days) | Catheter (day of removal/culture result) | Other foci | Death |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ALL (pre-B) (de novo)/induction | No | No | 28 | 1,157/16 | 27 | L-Amb | Aug 2004 | 2 | 1, Pos | None | No |
| 2 | AML (de novo)/induction | Yes | No | 18 | 0/12 | 18 | None | Oct 2005 | 1 | 2, Neg | None | No |
| 3 | Bilineage leukemia (de novo)/consolidation | No | No | 126 | 0/5 | 15 | None | Sep 2008 | 1 | 1, Neg | None | No |
| 4 | AML (de novo)/induction | No | No | 43 | 0/15 | 18 | Mica | Jul 2009 | 2 | 2, Neg | None | Yes |
| 5 | AML (relapsed)/salvage | Yes | No | 20 | 0/20 | 13 | None | Aug 2009 | 2 | 2, ND | None | No |
| AML (relapsed)/salvage | No | No | None | 0/30 | 58 | L-Amb, 5FC | Jul 2010 | 6 | Bladder fungus ball | Yes | ||
| 6 | AML (relapsed)/salvage | No | No | 19 | 0/15 | 18 | None | Oct 2009 | 3 | 1, Neg | None | No |
| 7 | AML (relapsed)/salvage | No | No | 75 | 0/25 | 17 | Mica | Jan 2010 | 9 | 14, Neg | Retina | Yes |
| 8 | AML (relapsed)/induction | Yes | Yes | 23 | 0/13 | 23 | Mica | Aug 2010 | 2 | 1, Neg | None | No |
a
Abbreviations: AML, acute myelogenous leukemia; ALL, acute lymphoblastic leukemia; TPN, total parenteral nutrition; ANC, absolute neutrophil count; Mica, micafungin; L-Amb, liposomal amphotericin B; 5FC, flucytosine; Pos, positive; Neg, negative; ND, not determined; Jan, January; Jul, July; Aug, August; Sep, September; Oct, October.