Fig. 5.

CB₂ receptors are not required for the expression of mecamylamine-precipitated withdrawal responses in nicotine-dependent mice. CB₂ (−/−) and (+/+) mice implanted with nicotine mini pumps and challenged with mecamylamine (2 mg/kg, s.c.) displayed similar: a anxiogenic-like responses, as reflected by a pronounced decrease of time spent in the open arms of elevated plus maze test, b total number of somatic withdrawal signs, and c hyperalgesic responses in the hot plate test. Data are depicted as mean± SEM, n=6 per group; ***p<0.001 vs saline for each respective genotype