. Author manuscript; available in PMC: 2014 Jun 3.

Published in final edited form as: Int J Mycobacteriol. 2013 Mar 20;2(2):73–78. doi: 10.1016/j.ijmyco.2013.02.002

Table 1.

The most common drug resistance mutations of rpoB, katG and inhA of M. tuberculosis MDR isolates fromnew versus previously treated TB cases.

Mutation	No. (detection %) of MDR isolates from			P value^*

	All cases (n = 634)	New cases (n = 259)	Previously treated cases (n = 375)
rpoB S531L	426 (67.2)	208 (80.30)	218 (58.1)	≤0.000001
rpoB H526Y	13 (2.1)	4 (1.5)	9 (2.4)	0.45
rpoB H526D	7 (1.1)	4 (1.5)	3 (0.8)	0.37
rpoB D516V	33 (5.2)	16 (6.2)	17 (4.5)	0.35
katG S315T	535 (84.3)	252 (97.3)	283 (75.5)	≤0.000001
inhA C (−15) T	143 (22.6)	69 (26.6)	74 (19.7)	0.02
inhA T (−8) C	8 (1.3)	2 (0.8)	6 (1.6)	0.48

Total – 465, 169 isolates not including in the table: No mutation on rpoB – 110, Single mutation only on rpoB – 14, Single mutation only on katG – 7, Single mutation only on inhA – 2, Without any mutations – 36.