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. Author manuscript; available in PMC: 2014 Jun 3.
Published in final edited form as: Nat Struct Mol Biol. 2009 Sep 20;16(10):1101–1108. doi: 10.1038/nsmb.1668

Figure 4.

Figure 4

Specificity of caspase-3 and GluC. WebLogo representations of protease cleavage-sites depict the amino acid conservation and frequency at each position. The classic human caspase-3 consensus sequence DEVD↓G based on peptide positional scanning libraries 7,8 is recapitulated with two notable exceptions: there is no conservation at P3 and a weak additional preference for small uncharged amino acids at P2’ (a). GluC is not known to possess any extended specificity 32; however, we see a weak preference for hydrophobic residues in the P1’ position (b).