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. 2013 Oct 8;105(22):1738–1749. doi: 10.1093/jnci/djt271

Figure 2.

Figure 2.

Effects of synbindin on the proliferation and invasion of gastric cancer cells. A) Flow cytometry assay of MGC803 and SGC7901 cells treated by synbindin small interfering RNA (siRNA). The knockdown of synbindin induced increase of cells in subG1 and G2 phases as compared with control siRNA. The bars indicate mean values with 95% confidence interval. B) Apoptosis of MGC803 and SGC7901 cells induced by knockdown of synbindin. Flow cytometric assay based on phycoerythrin (PE)–conjugated annexin V staining showed increased apoptosis of MG803 and SGC7901 cells treated by synbindin siRNA. The bars indicate mean values with 95% confidence interval. C) Knockdown of synbindin suppressed migration of gastric cancer cells. The MGC803 and SGC7901 cells were transfected by synbindin siRNAs, and Transwell assay was applied to quantify cell migration ability. D) Representative Transwell cell staining images of MGC803 and SGC7901 cells. Scale bars indicate 50 μm. E) The human gastric epithelial immortalized GES-1 cells were infected with adenovirus that carried synbindin, and cell migration was detected by Transwell assay. The bar plot indicates mean values with 95% confidence interval. F) Representative Transwell cell staining images of GES-1 cells. Scale bars indicate 50 μm.