Fig. 3.

FDG accumulations according to the administration route in the tumor model. a, b Multiple static FDG PET scans were undertaken in 18 tumor-bearing mice at 10, 20, 30, 40, 50, 60, 120 and 180 min using the IV, RO, IP and PO methods. A volume of interest was drawn on the tumor, and the mean SUV was calculated. 8 × 10⁷ CRL-1642 cells per mouse were inoculated in 24 mice. c, d Serial FDG PET scans were done 60 min after FDG administration during 4 weeks with the IV and RO routes by turns, and then with the IV and IP routes by turns. A volume of interest was drawn on the tumor, and the mean SUV was calculated. IV: intravenous, RO: retroorbital, IP: intraperitoneal, PO: per oral