Table I.

Model parameters estimated from a simultaneous analysis of experiments on apoptosis induction in rat fibroblasts by externally added signalling species (Figure 2 and Supplementary Material, available at Carcinogenesis Online) and from model adaptation to intercellular induction of apoptosis by the HOCl pathway in the coculture system with transformed and non-transformed cells (Figure 3)

Parameter		Value
n1	Characteristic level of membrane LPO leading to apoptosis induction (mol/cell)	10−17
n2	Rate of change in apoptosis induction probability with increasing LPO (1)	3.5
tind	Characteristic time of apoptosis induction (h)	1.7
trm	Characteristic time of removal of apoptotic bodies (h)	15
trep	Characteristic time of LPO repair (h)	15
tO2 − ·	O2 − · lifetime (s)	1.7
tH2O2	H2O2 lifetime (h)	2.7
tOH	·OH lifetime (μs)	3.4
tHOCl	HOCl lifetime (ms)	38
αO2 − ·	Release rate of O2 − · per transformed cell (mol/cell/s)	10−16
αPOD	Release rate of POD per TGF-β pretreated normal cell (mol/cell/s)	10−21

Parameters relevant for model calibration only are reported in Supplementary Material, available at Carcinogenesis Online.