Fig. 5.

PPARβ activation induces expression of angiogenic markers. Densitometric analyses of tibialis anterior lysates from GW0742-treated adult mice. Expression levels of vascular endothelial growth factor-A (VEGF-A) and platelet endothelial cell adhesion molecule 1 (PECAM-1) were determined as described in materials and methods. TBP was used as internal standard. For each time and condition, values are plotted as fold change vs. animals receiving vehicle only for 2 h and are means ± SD from 5 animals of each group. *P < 0.05 vs. controls; ^aP < 0.05 vs. other time points of GW treatment; ^bP < 0.05 vs. 2, 8, 24, and 96 h of GW treatment; ^cP < 0.05 vs. 2, 5, 8, and 96 h; ^dP < 0.05 vs. 2, 8, and 24 h of GW treatment; ^eP < 0.05 vs. 2, 5, 8, and 24 h of GW treatment.