Table III.

OR and 95% CI for the main effect of SNPs in genes involved in iron homeostasis with P <0.05 on advanced colorectal adenoma and colorectal cancer in the PLCO Cancer Screening Trial

SNP	Gene	Effect allele	EAF	ORa	95% CI	P-valueb
Advanced colorectal adenoma
rs12236816	ACO1	G	0.05	1.32	1.03, 1.68	0.03
rs16861634	CP	T	0.11	0.80	0.66, 0.96	0.02
rs701754	CP	T	0.17	0.85	0.73, 0.98	0.03
rs10935744	CP	A	0.11	0.82	0.69, 0.99	0.04
rs7580094	CYBRD1	G	0.26	0.84	0.74, 0.95	0.01
rs1042265	FTL	A	0.12	0.83	0.70, 0.99	0.04
rs7116300	HEPHL1	G	0.43	1.18	1.06, 1.31	0.00328
rs1401186	HEPHL1	C	0.45	1.18	1.06, 1.31	0.00345
rs16919942	HEPHL1	T	0.10	1.23	1.03, 1.46	0.02
rs1800702	HFE	G	0.39	1.14	1.02, 1.27	0.02
rs2270367	HMOX2	A	0.05	1.31	1.02, 1.68	0.03
rs706803	SLC11A2	A	0.06	0.76	0.59, 0.98	0.04
Colorectal cancer
rs7855483	ACO1	C	0.17	1.56	1.21, 2.01	0.0006
rs10970971	ACO1	G	0.45	0.71	0.57, 0.88	0.0018
rs1023087	ACO1	G	0.20	1.41	1.10, 1.79	0.006
rs17288067	ACO1	A	0.17	1.42	1.10, 1.83	0.007
rs11793098	ACO1	G	0.28	1.29	1.03, 1.61	0.02
rs7866419	ACO1	A	0.38	1.27	1.03, 1.56	0.03
rs10758138	ACO1	T	0.46	0.80	0.65, 0.98	0.03
rs8043138	B2M	T	0.05	1.56	1.02, 2.40	0.04
rs4645900	FTL	T	0.04	0.46	0.24, 0.89	0.02
rs905238	FTL	G	0.48	0.80	0.65, 0.98	0.03
rs1045537	HFE	C	0.08	1.49	1.00, 2.07	0.02
rs2071303	HFE	C	0.29	1.28	1.03, 1.59	0.03
rs4970862	HFE2	T	0.32	1.34	1.09, 1.66	0.006
rs10282088	IGFBP3	A	0.16	1.35	1.04, 1.76	0.02
rs10255707	IGFBP3	T	0.20	1.29	1.01, 1.66	0.04
rs12702181	IGFBP3	G	0.37	0.81	0.65, 1.00	0.05
rs12638146	TF	T	0.01	3.11	1.29, 7.50	0.01
rs1370593	SLC40A1	A	0.38	1.24	1.01, 1.52	0.04

EAF, effect allele frequency among Caucasian controls.

^aOR per risk allele assuming a log-additive model, adjusted for age, sex and ethnicity.

^bNo associations were significant at P < 0.05 after adjustment for multiple comparison testing.