Table III.

Replication result of top SNPs associated with recurrence in NSCLC patients treated with surgery-only

SNP	MD Anderson	P	MOIa	Mayo Clinic recur (yes/no)			Mayo Clinic	P	Meta	Meta P
	HRb (95% CI)			WW	WV	VV	HRb (95% CI)		HRb (95% CI)
rs2536182	0.47 (0.28–0.80)	5.24×10 −3	Dom	12/67	9/146	5/57	0.39 (0.18–0.84)	0.0162	0.44 (0.29–0.68)	2.30×10 −4
rs10898563c	2.98 (1.60–5.35)	0.0004	Rec	12/11	100/129	3/38	0.81 (0.24–2.75)	0.7409	2.31 (1.33–3.96)	0.0246

Significant P values (P < 0.05) in bold type. VV, homozygous variant genotype;

WW, homozygous wild-type genotype; WV, heterozygous variant genotype.

^aMOI: model of inheritance, the model with the smallest P value for both discovery and replication groups; Dom, dominant; Rec, recessive.

^bAdjusted by age, sex, smoking status, cancer stage and treatment regimen.

^cInformation for three samples from the Mayo Clinic was missing due to failed genotyping assay.