Table IV.
Cumulative effect of treatment-based exploratory predictive markers on recurrence risk in NSCLC patients stratified by treatment
| Markers based on surgery-only | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Number of unfavorable genotypes | Surgery-only | Surgery and chemotherapy | ||||||||
| Recur, n (%) | No recur, n (%) | HR | P value | Log- rank P | Recur, n (%) | No recur, n (%) | HR | P value | Log- rank P | |
| 0–9 | 6 (10.3) | 78 (37.5) | 1 (reference) | 14 (45.2) | 20 (27.4) | 1 (reference) | ||||
| 10–12 | 12 (20.7) | 87 (41.8) | 2.24 (0.81–6.19) | 0.1186 | 11 (35.5) | 27 (37.0) | 0.56 (0.25–1.24) | 0.1523 | ||
| ≥13 | 40 (69.0) | 43 (20.7) | 11.09 (4.59–26.80) | 8.93×10−8 | 4.77×10−13 | 6 (19.4) | 26 (35.6) | 0.30 (0.11–0.82) | 0.0184 | 0.1119 |
| Markers based on surgery and chemotherapy | ||||||||||
| Number of unfavorable genotypes | Surgery-only | Surgery and chemotherapy | ||||||||
| Recur, n (%) | No recur, n (%) | HR | P value | Log- rank P | Recur, n (%) | No recur, n (%) | HR | P value | Log- rank P | |
| 0–5 | 30 (52.6) | 68 (32.2) | 1 (reference) | 1 (3.2) | 35 (47.9) | 1 (reference) | ||||
| 6–7 | 17 (29.8) | 78 (37.0) | 0.57 (0.31–1.04) | 0.0682 | 8 (25.8) | 24 (32.9) | 11.07 (4.38–79.05) | 0.0244 | ||
| ≥8 | 10 (17.5) | 65 (30.8) | 0.41 (0.20–0.85) | 0.0171 | 0.0201 | 22 (71.0) | 14 (19.2) | 54.56 (7.21–413.2) | 1.08×10−4 | 9.95×10−9 |
Unfavorable genotypes for surgery-only markers: rs10898563 (VV), rs757558 (WV + VV), rs4074947 (WV + VV),
rs3781586 (WW + WV), rs3765351 (WV + VV), rs11922919 (WW + WV), rs557077 (WW), rs4257529 (WV + VV),
rs3923087 (WV + VV), rs7591 (WV + VV), rs7526484 (VV), rs566926 (WV + VV), rs288326 (WV + VV),
rs648872 (VV), rs8192633 (WV + VV), rs10127943 (WV + VV), rs12816278 (WV + VV), rs2163910 (WV + VV),
rs8068404 (WV + VV), rs11650531 (WV + VV), rs12632968 (WV + VV), rs4968281 (WV + VV), rs314756 (WV + VV),
rs640569 (WV + VV), rs4919139 (VV) and rs390258 (WV + VV).
Unfavorable genotypes for surgery and chemotherapy markers: rs11725638 (WV + VV), rs10891310 (VV), rs4919139 (VV),
rs9864832 (WV + VV), rs9675157 (WV + VV), rs4958216 (WV + VV), rs2163910 (WV + VV), rs1722846 (VV), rs395901 (WV + VV),
rs2039826 (VV), rs7478323 (VV), rs2707761 (WV + VV), rs2277268 (WV + VV), rs2240511 (WV + VV), rs9872276, (VV),
rs4730775 (WV + VV), rs4956157 (VV), rs7301320 (WV + VV), rs10917155 (WV + VV) and rs7296858 (WV + VV). V, variant;
W, wild-type.