Table III.
Variable | HPV16/18 positive | |||||
---|---|---|---|---|---|---|
All studies (N = 3163) | Small studiesa (N = 918) | Large studiesb (N = 2245) | ||||
ORc (95% CI) | P value | ORc (95% CI) | P value | ORc (95% CI) | P value | |
Gender | 0.141 | 0.049 | 0.824 | |||
Male | 1.0 (ref.) | 1.0 (ref.) | 1.0 (ref.) | |||
Female | 1.27 (0.92, 1.75) | 1.61 (1.00, 2.59) | 1.05 (0.68, 1.62) | |||
Age (years) | 0.420 | 0.029 | 0.361 | |||
≤66 | 1.0 (ref.) | 1.0 (ref.) | 1.0 (ref.) | |||
>66 | 1.13 (0.84, 1.54) | 1.65 (1.05, 2.59) | 0.82 (0.54, 1.25) | |||
Race | 0.029 | 0.708 | < 0.001 | |||
Othersd | 1.0 (ref.) | 1.0 (ref.) | 1.0 (ref.) | |||
White | 0.33 (0.12, 0.90) | 0.80 (0.25, 2.59) | 0.08 (0.02, 0.33) | |||
Smoking history | 0.930 | 0.859 | 0.974 | |||
Never smoked | 1.0 (ref.) | 1.0 (ref.) | 1.0 (ref.) | |||
Ever smoked | 1.02 (0.66, 1.57) | 1.06 (0.58, 1.91) | 1.01 (0.59, 1.74) | |||
Histology | 0.812 | 0.576 | 0.827 | |||
Otherse | 1.0 (ref.) | 1.0 (ref.) | 1.0 (ref.) | |||
SCC | 1.05 (0.71, 1.54) | 1.16 (0.69, 1.93) | 0.94 (0.53, 1.66) | |||
Tumor stage | 0.561 | 0.044 | 0.338 | |||
I/II | 1.0 (ref.) | 1.0 (ref.) | 1.0 (ref.) | |||
III | 0.87 (0.56, 1.37) | 0.94 (0.53, 1.66) | 0.78 (0.36, 1.68) | |||
IV | 1.10 (0.66, 1.85) | 2.55 (1.08, 6.04) | 0.68 (0.36, 1.27) |
Ref.: reference level.
aSmall studies include studies with 22 ≤ number of cases ≤ 99.
bLarge studies include studies with 131 ≤ number of cases ≤ 399.
cStudy was included as a random effect.
dOthers include Asian, Black, Hispanic and race not specified.
eOthers include adenocarcinoma and histology not specified.