Fig. 2.

Oral administration of GE exhibited enhanced inhibition of human prostate tumor xenograft growth in nude mice compared with Mix. Male nude mice were subcutaneously injected with 10⁶ PC-3-luc cells. (A) Representative bioluminescent images of one animal per group indicating progression of tumor growth over 4 weeks. (B) Graphical representation of quantitative radiance measured as the number of photons leaving a square centimeter of tissue and radiating into a solid angle of 1 steradian (photons/sec/cm²/sr) from control vehicle, GE- and Mix-fed mice for 4 weeks. (C) Tumor growth monitored (by vernier calipers) and presented as tumor volume in cubic millimeter, over a period of 4 weeks. (D) Graphical representation of body weight of vehicle, GE- and Mix-treated mice. (E) Graphical representation of tumor weight. (F) Representative photographic images of excised tumors [*P < 0.05 (two-way analysis of variance), as compared with controls; B, C and E]. Error bars refer to ±SD. Statistical significance in percent tumor growth between control and treatment groups was achieved after week 3.