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. 2014 Jan 15;35(6):1320–1329. doi: 10.1093/carcin/bgu011

Table II.

PK parameters of gingerols following oral gavage administration of GE and Mix in C57BL/6J mice (dose GE: 250mg/kg; Mix: prorated to amount present in GE)

Analyte T max (h) C max (ng/ml) MRT (h) AUClast (ng*h/ml), PO Bioavailability, F Fold increase in F
GE Mix GE Mix GE Mix GE Mix GE Mix
6G 0.17 0.08 305.9±92.45 300.69±2.95 3.95 3.34 219.04 137.97 110 69 1.6
8G 0.17 0.08 71.74±32.61 144.71±0.49 2.81 1.45 48.65 44.49 84 77 1.1
10G 0.17 0.08 327.26±40.12 756.62±7.62 4.57 1.34 957.34 281.56 385 113 3.4
6S 0.17 0.08 5.68±0.18 10.57±4.72 4.63 2.10 7.37 2.97 330 133 2.5

F, bioavailability—calculated using dose normalized AUClast; MRT: mean residence time; PO, single oral dose.