Table 2.
Association Between High Myopia and 16 Single Nucleotide Polymorphisms of the MYOC, HGF, MET, and ACAN Genes in the Han Chinese Population
| Gene | SNP | Chr | BP | Minor allele | Number (case/control) | MAF (case/control) | p_HWE (case/control) | p_allelica | Odds ratio (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| MYOC | rs235858 | 1 | 169863125 | C | 1052/1070 | 0.494/0.503 | 0.322/0.087 | 0.5588 | 0.96 (0.86, 1.09) |
| rs2421853 | 1 | 169866576 | A | 1046/1064 | 0.210/0.194 | 0.843/0.033 | 0.1887 | 1.11 (0.95, 1.29) | |
| rs7545646 | 1 | 169873362 | C | 1019/1039 | 0.012/0.013 | 0.704/0.671 | 0.7242 | 0.91 (0.52, 1.57) | |
| rs16864720 | 1 | 169878890 | A | 1048/1064 | 0.012/0.013 | 0.684/0.675 | 0.9341 | 0.98 (0.57, 1.68) | |
| rs7523603 | 1 | 169880993 | C | 1046/1062 | 0.259/0.278 | 0.878/0.363 | 0.1601 | 0.91 (0.79, 1.04) | |
| rs235920 | 1 | 169888598 | C | 1050/1064 | 0.436/0.428 | 0.403/0.001 | 0.6173 | 1.03 (0.91, 1.17) | |
| rs2075537 | 1 | 169890456 | T | 1045/1068 | 0.437/0.459 | 0.266/0.694 | 0.1603 | 0.92 (0.81, 1.04) | |
| HGF | rs2286194 | 7 | 81193385 | A | 1050/1064 | 0.184/0.193 | 0.006/0.490 | 0.4859 | 0.95 (0.81, 1.10) |
| rs3735520 | 7 | 81238875 | T | 1052/1066 | 0.438/0.443 | 0.103/0.709 | 0.7648 | 0.98 (0.87, 1.11) | |
| MET | rs9641562 | 7 | 116110027 | C | 1050/1068 | 0.090/0.104 | 0.004/0.034 | 0.1128 | 085 (0.69, 1.04) |
| rs38857 | 7 | 116152649 | T | 1052/1066 | 0.110/0.096 | 0.295/0.041 | 0.1305 | 1.17 (0.96, 1.42) | |
| rs10215153 | 7 | 116186367 | A | 1052/1070 | 0.105/0.091 | 0.842/0.012 | 0.1147 | 1.18 (0.96, 1.44) | |
| rs2073560 | 7 | 116210397 | A | 1049/1068 | 0.288/0.304 | 0.790/0.434 | 0.2703 | 0.93 (0.81, 1.06) | |
| rs1621 | 7 | 116224842 | G | 1050/1068 | 0.132/0.122 | 0.707/0.579 | 0.3197 | 1.10 (0.91, 1.31) | |
| ACAN | rs3784757 | 15 | 87204408 | T | 1052/1068 | 0.131/0.154 | 0.401/0.390 | 0.0334 | 0.83 (0.70, 0.99) |
| rs1516794 | 15 | 87205907 | T | 1052/1068 | 0.084/0.104 | 0.584/0.418 | 0.0236 | 0.79 (0.64, 0.97) |
a
p-values were adjusted for age and sex.
BP, base position; Chr, chrosome; MAF, frequency of minor allele; p_HWE, the p_value of Hardy–Weinberg equilibrium; CI, confidence interval; SNP, single nucleotide polymorphism.