Table 3.
Genotype Analysis of rs38857, rs10215153, and rs3784757 in High Myopia Cases and Controls
| Gene | SNP | Chr | BP | Genotype | Case n (%) | Control n (%) | p | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|
| MET | rs38857 | 7 | 116152649 | TT | 16 (1.5) | 4 (0.4) | 0.0064 | 4.14 (1.38, 12.43) |
| CT | 199 (18.9) | 196 (18.4) | ||||||
| CC | 837 (79.6) | 866 (81.2) | ||||||
| MET | rs10215153 | 7 | 116186367 | AA | 11 (1.0) | 2 (0.2) | 0.0113 | 5.74 (1.27, 25.95) |
| AG | 199 (18.9) | 190 (17.8) | ||||||
| GG | 842 (80.0) | 878 (82.1) | ||||||
| ACAN | rs3784757 | 15 | 87204408 | TT | 15 (1.4) | 29 (2.7) | 0.0373 | 0.52 (0.28, 0.97) |
| CT | 246 (23.4) | 271 (25.4) | ||||||
| CC | 791 (75.2) | 768 (71.9) |
p, the p-value of recessive model; OR, the odds ratio of homozygote.