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. Author manuscript; available in PMC: 2014 Jun 3.
Published in final edited form as: J Drug Target. 2013 Sep 16;21(10):956–967. doi: 10.3109/1061186X.2013.837470

Figure 2.

Figure 2

Hydrodynamic diameters of PMLA nanoconjugates assuming spherical particles are shown as a function of calculated molecular weights. Data points numbered 1–4 (circles) refer to free polymalic acid of different molecular weight, and data points numbered 5–8 (circles) refer to various nanodrugs. All other data points (squares) refer to PMLA-based nanodrugs of different composition regarding antibodies, AONs, endosome escape units (LLL or LOEt), mPEG, and in several cases chemotherapeutics synthesized by us and published before [20,31,42]. Diameters were calculated by the Malvern Zetasizer software (Malvern Instruments, Malvern, UK). Free PMLA and various nanoconjugates with loads of different composition are compared. Molecular weights of PMLA were obtained by sec-HPLC method with polystyrene sulfonate as standards and for nanoconjugates by calculation according to their structures. Indicated numbers refer to: 1–4. PMLA Mw 20 000–100 000; 5. P; 6. P/AONEGFR MsTfR-HuTfR; 7. P/AONα4,β1 MsTfR-HuTfR; 8. P/AONEGFRα4,β1 MsTfR-HuTfR.