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. 2014 Jun 3;9(6):e93415. doi: 10.1371/journal.pone.0093415

Figure 3. Time-dependent changes in HIV-1 subtype A genomic variability.

Figure 3

HIV-1 gag variability was measured for all five year-groups using a) G→A substitutions and b) Shannon entropy. a) G→A substitutions: Small black circles represent number of substitutions for each sequence; grey lines show the mean for a particular year-group. The red line over the scatter plot represents statistically significant (p<0.001) differences between groups. b) Shannon entropy analysis: The vertical axis represents entropy scores, while the horizontal axis shows position of amino acids in the gag gene. Shannon entropy scores for each year-group are represented in the following colors: 1985–90 (turquoise), 1990–95 (purple), 1995–00 (green), 2000–05 (red) and 2005–2010 (blue) Insert: Mean entropy score for each year-group was calculated and plotted using GraphPad software. Red line over bars represents a statistically significant difference between the groups (p<0.001). Error bars represent the standard error of the mean.