Table 2. Regions showing lower fractional anisotropy (FA) values in HIV-negative chronic meningitis (n = 32) than in normal controls (n = 32).

MNI atlas coordinates			Voxel size	White matter tract	Nearest Grey MatterΨ	FA mean (SD)		tmax	Diffusivity values (Meningitis-Normal)
X	Y	Z				Normal	Meningitis		MD	AD	RD
−22	−62	−2	29	Left Inferior Longitudinal Fasciculus	Para-hippocampal Gyrus, BA19	0.34 (0.08)	0.26 (0.07)	4.17	44.5	−28.4	81*
20	−64	0	31	Right Inferior Longitudinal Fasciculus	Para-hippocampal Gyrus, BA 19	0.35 (0.07)	0.28 (0.08)	4.11	44.3*	−13.6	73.2*
8	16	28	37	Right Cingulum	Cingulate Gyrus, BA24	0.55 (0.10)	0.47 (0.12)	3.82	170.5	82.2	214.7*
24	14	28	110	Right Superior Corona Radiata	Cingulate Gyrus, BA32	0.41 (0.04)	0.37 (0.04)	3.82	67.6*	45.9	78.5*
−22	−70	16	27	Left Forceps Major	Cuneus, BA30	0.45 (0.11)	0.35 (0.16)	3.76	34.7	−76.3*	90.2*
−32	−8	32	21	Left Superior Longitudinal Fasciculus	Pre-central Gyrus, BA 6	0.32 (0.05)	0.28 (0.04)	3.73	39.4	14.3	51.9*
−20	−12	38	21	Left Superior Corona Radiata	Cingulate Gyrus, BA 24	0.35 (0.05)	0.31 (0.04)	3.72	127.6	116.2	133.3*
−18	4	−4	29	WM close to Left Globus Pallidus	Lentiform Nucleus	0.38 (0.07)	0.31 (0.06)	3.62	42.9	−19.7	74.3*

The diffusivity values describe differences (meningitis vs. normal) in mean diffusivity (MD), axial diffusivity (AD), and radial diffusivities (RD) (mm²/s) multiplied by 10⁻⁶.

*Significant differences among MD, AD, and RD were adjusted with age, sex, and education as covariates (p≤0.05).

^ΨNearest Gray Matter was near the center of the 5-mm radius search area.

Abbreviations: MNI, Montreal Neurological Institute; BA, Brodmann area.