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. 2014 Apr 3;7(6):1611–1616. doi: 10.3892/etm.2014.1662

Figure 4.

Figure 4

Effects of RES and DOX on MDR-1 gene and protein expression in MCF-7/DOX cells. (A and C) Lane 1, MDR-1 gene expression levels in MCF-7/DOX cells; lanes 2, 3, 4 and 5, treatment with 8 μM DOX, 10 μM RES, 6 μM DOX combined with 8 μM RES, 10 μM DOX combined with 12 μM RES for 48 h, respectively; β-actin, control; lane M, DNA ladder. (B and D) Lane 1, protein expression of P-gP in MCF-7/DOX cells; lanes 2, 3, 4 and 5, treatment with 8 μM DOX, 10 μM RES, 6 μM DOX combined with 8 μM RES, 10 μM DOX combined with 12 μM RES for 48 h, respectively. *P<0.05 compared with lane 1. MDR, multidrug resistance; RES, resveratrol; DOX, doxorubicin.