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. 2014 Mar 28;7(6):1653–1658. doi: 10.3892/etm.2014.1647

Figure 4.

Figure 4

Curcumin suppresses TNF-α-induced MMP-2 expression. (A) VSMCs were pretreated with 40 μM curcumin and 10 μM BAY11-7082 for 1 h and exposed to 100 ng/ml TNF-α for an additional 23 h. Following treatment, the protein expression levels of MMP-2 were determined by western blot analysis. (B) Densitometric analysis was conducted with Image J software to quantify the western blot data. *P<0.05, vs. control group; #P<0.05, vs. TNF-α-treated group. Data are expressed as the mean ± standard deviation of three independent experiments. VSMCs, vascular smooth muscle cells; TNF, tumor necrosis factor; MMP, matrix metalloproteinase.