Table 3.

Dependence of the inhibition of ABCG2-mediated mitoxantrone efflux on B-ring substituents in chalcones containing either a 3,4-methylenedioxyphenyl or 2-naphthyl group at the A-ring

Note: ^aThe inhibitory efficiency of the chalcones was studied as above.

Abbreviations: ABCG2, ATP-binding cassette super family G2 (also called breast cancer resistance protein); IC₅₀, concentration producing 50% inhibition.